I use an M1 Mac, and chips like the PL2303, CH340, and CP210, which have ARM architecture drivers and support serial communication, can be directly used with macOS (using CHIRP), virtual machines, or Wine for serial communication.
In addition to the frequency generator, there is also an FT-891 radio. Since the serial port is also CP210, and FT8-related software has a Mac version, it's perfectly fine to natively flash FT8 on a Mac without needing a virtual machine.
Like Hytera's walkie-talkie systems, which use proprietary software without ARM versions, Mac or virtual machines cannot run them. If you absolutely must use an M1 Mac, you can install UTM and then install Windows 7 within it using "simulation," but the system performance and USB stability will be very poor. It is better to use a traditional x86 computer instead.